Connectivity Map

Connectivity Map. Connectivity Map (CMap) analysis in MDAMB468 cells exposed to The Research Article "The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease" (29 Sept To build a Connectivity Map, the Broad brings together molecular biologists, genomics specialists, computational scientists, pharmacologists, chemists and chemical biologists, as well as expertise from across the breadth and depth of.

The Connectivity Map is a collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules and simple pattern-matching algorithms that together enable the discovery of decisive functional connections between drugs, genes, and diseases To date, CMap has generated a library containing over 1.5M gene expression profiles from ~5,000 small-molecule compounds, and ~3,000 genetic reagents, tested in multiple cell types

World Map Connectivity Matrix Visual

But this remains a daunting task, and even the most inspired researchers still have to resort to laborious screens of genetic or chemical libraries. To build a Connectivity Map, the Broad brings together molecular biologists, genomics specialists, computational scientists, pharmacologists, chemists and chemical biologists, as well as expertise from across the breadth and depth of. The Connectivity Map is a collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules and simple pattern-matching algorithms that together enable the discovery of decisive functional connections between drugs, genes, and diseases

Visualize your LinkedIn network with InMaps Official LinkedIn Blog. Lamb et al.' (1) is biased in favor of establishing the usefulness of a connectivity map for revealing connections among small molecules, genes, and diseases by generating gene-expression. The second challenge in the 2016 Connectivity Map series asked competitors to speed up the existing algorithm.

Connection Map Data Viz Project. These are the questions the Connectivity Map project set. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs